Aqua Tofana

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What Wikipedia says

Aqua Tofana (also known as Acqua Toffana and Aqua Tufania) was a strong, arsenic-based poison created in Sicily around 1630 that was reputedly widely used in Palermo, Naples, Perugia, and Rome, Italy, during the Renaissance.

Excerpt from the Wikipedia article “Aqua Tofana”, under the CC BY-SA 4.0 license. Read the article on Wikipedia

Image: Gravure dessinée par Pierre Méjanel et gravée par François Pannemaker., Public domain, via Wikimedia Commons.