Cocoliztli epidemics

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What Wikipedia says

The Cocoliztli Epidemic or the Great Pestilence was an outbreak of a mysterious illness characterized by high fevers and bleeding which caused 5–15 million deaths in the North American territory of New Spain during the 16th century. The Aztec people called it cocoliztli, Nahuatl for pestilence.

Excerpt from the Wikipedia article “Cocoliztli epidemics”, under the CC BY-SA 4.0 license. Read the article on Wikipedia

Image: en:Bernardino de Sahagún (1499-1590), compiler. Original illustration by unknown 16th-century artist; this version of the drawing by unknown 16th-century copyist., Public domain, via Wikimedia Commons.