Two-hit hypothesis

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Work

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Arts and letters

Knowledge cost

2

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What Wikipedia says

The two-hit hypothesis, also known as the Knudson hypothesis, is the hypothesis that most tumor suppressor genes require both alleles to be inactivated, either through mutations or through epigenetic silencing, to cause a phenotypic change.

Excerpt from the Wikipedia article “Two-hit hypothesis”, under the CC BY-SA 4.0 license. Read the article on Wikipedia