Germinal center

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Notion

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Science and technology

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What Wikipedia says

Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response; most of the germinal center B cells (BGC) are removed by tingible body macrophages.

Excerpt from the Wikipedia article “Germinal center”, under the CC BY-SA 4.0 license. Read the article on Wikipedia

Image: Caitlin J. Gracie, CC BY 4.0, via Wikimedia Commons.