Muller's ratchet

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What Wikipedia says

In evolutionary genetics, Muller's ratchet (named after American geneticist Hermann Joseph Muller, by analogy with a ratchet effect) is a process which, in the absence of recombination (especially in an asexual population), results in an accumulation of irreversible deleterious mutations.

Excerpt from the Wikipedia article “Muller's ratchet”, under the CC BY-SA 4.0 license. Read the article on Wikipedia

Image: Auteur inconnu, Public domain, via Wikimedia Commons.